618.3-008.6-092.9
Background: Preeclampsia (PE), a hypertensive disorder associated with pregnancy, is a leading cause of both maternal and neonatal morbidity and mortality. Ongoing research into the genetic factors underlying this condition is significant, but the role of the renin-angiotensin system gene polymorphism (rs699), has yielded varied and inconclusive results, with discrepancies in findings across different geographical and ethnic populations. The aim of this study: This meta-analysis is aimed to establish a more robust and dependable correlation between AGT (rs699) polymorphism and the risk of PE. Materials and methods: A comprehensive literature search for relevant studies was performed in electronic databases between January 2017 and December 2024. A total of 13 studies were included in this meta-analysis. Odds ratios (ОRs) and 95 % confidence intervals (СIs) were calculated using five genetic models to assess the strength of the association, and a heterogeneity test was performed. Results: The results revealed a statistically significant association between the AGT rs699 polymorphism and the risk of developing РЕ in all genetic models, including dominant (ОR = 1,73, 95 % CI [1,45–2,05], p <0,00001), recessive (ОR = 1,46, 95 % CI [1,14–1,87], p = 0,03), homozygote (ОR = 2,03, 95 % CI [1,37–3,00], p = 0,0004), and heterozygote (ОR = 1,26, 95 % CI [1,05–1,52], p <0,00001) models. No heterogeneity was observed in two genetic models (dominant and heterozygote, I2 = 18 % and 0 %, respectively). For subgroup analysis, a number of significant associations were identified. However, the analysis of subgroups based on race revealed an absence of significant associations in the mongoloid and negroid subgroups. It should be noted that only a single study was analysed in these specific subgroups, which may limit the robustness of the findings. No evidence of publication bias Egger's test р-value > 0,05 in all genetic models. Conclusion: Our results indicate that the AGT rs699 polymorphism is significantly associated with an increased risk of РЕ. This increased risk was also observed in all subgroups analysis, except for Negroid and Mongoloid in racial subgroups.
10.18522/2308-9709-2024-50-9
Background: Preeclampsia (PE), a hypertensive disorder associated with pregnancy, is a leading cause of both maternal and neonatal morbidity and mortality. Ongoing research into the genetic factors underlying this condition is significant, but the role of the renin-angiotensin system gene polymorphism (rs699), has yielded varied and inconclusive results, with discrepancies in findings across different geographical and ethnic populations. The aim of this study: This meta-analysis is aimed to establish a more robust and dependable correlation between AGT (rs699) polymorphism and the risk of PE. Materials and methods: A comprehensive literature search for relevant studies was performed in electronic databases between January 2017 and December 2024. A total of 13 studies were included in this meta-analysis. Odds ratios (ОRs) and 95 % confidence intervals (СIs) were calculated using five genetic models to assess the strength of the association, and a heterogeneity test was performed. Results: The results revealed a statistically significant association between the AGT rs699 polymorphism and the risk of developing РЕ in all genetic models, including dominant (ОR = 1,73, 95 % CI [1,45–2,05], p <0,00001), recessive (ОR = 1,46, 95 % CI [1,14–1,87], p = 0,03), homozygote (ОR = 2,03, 95 % CI [1,37–3,00], p = 0,0004), and heterozygote (ОR = 1,26, 95 % CI [1,05–1,52], p <0,00001) models. No heterogeneity was observed in two genetic models (dominant and heterozygote, I2 = 18 % and 0 %, respectively). For subgroup analysis, a number of significant associations were identified. However, the analysis of subgroups based on race revealed an absence of significant associations in the mongoloid and negroid subgroups. It should be noted that only a single study was analysed in these specific subgroups, which may limit the robustness of the findings. No evidence of publication bias Egger's test р-value > 0,05 in all genetic models. Conclusion: Our results indicate that the AGT rs699 polymorphism is significantly associated with an increased risk of РЕ. This increased risk was also observed in all subgroups analysis, except for Negroid and Mongoloid in racial subgroups.
